Researchers at the University of Cagliari (Sardinia) have achieved a breakthrough in the rapidly developing field of nanomedicine by observing that metallic nanoparticles can penetrate and eventually permeate human skin.

Their study, published in the Journal of Investigative Dermatology, provides the first evidence that engineered nanoparticles can passively reach the viable epidermis through the SC (stratum corneum) matrix.

Biomedical applications for engineered nanoparticles that can penetrate and permeate the skin include cell labeling and targeting, tissue engineering, drug delivery, magnetic resonance imaging and detection/analysis of biomolecules such as proteins and pathogens.

While scientists are enthusiastic about such diagnostic and therapeutic applications, they are also cautious about possible health risks associated with nanoparticle skin absorption. Dr. Baroli’s ongoing research includes an assessment of potential toxicological risks.