Sanford-Burnham researchers discover molecule that controls tumor vessel maturation -- a counterintuitive approach that could improve cancer drug delivery
ORLANDO, Fla., August 13, 2012 – To survive, tumors need blood supply to provide them with nutrients and oxygen. To get that supply, cancer cells stimulate new blood vessel growth—a process called tumor angiogenesis. Many attempts have been made to inhibit this process as a means to choke off tumors. But tumor…Continue
Added by Emmanuel Gutierrez on September 5, 2012 at 11:00pm — No Comments
By combining a nanoparticle that is readily visible in X-ray computed tomography (CT) scans with a molecule that targets tumor lymph vessels and other tumor tissues, a research team from the University of California, San Diego (UCSD) and the Sanford-Burnham Medical Research Institute has developed a new imaging agent that provides high-fidelity CT images of tumors and their edges. This work, led by Michael Sailor of UCSD and Erkki…Continue
Added by MySDScience on January 24, 2012 at 11:30am — No Comments
The trouble with most anti-cancer therapies is that they are lethal to most cells in the body, not just cancer cells. As a result, patients experience side effects like nausea, increased susceptibility to infection, and increased risk of developing secondary cancers later in life. Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) are developing techniques to deliver cancer drugs directly to tumors, increasing their effectiveness and decreasing collateral damage. In…Continue
Added by MySDScience on November 21, 2011 at 12:00pm — No Comments
Scientists at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center, in collaboration with colleagues in Boston and South Korea, say they have identified a novel gene mutation that causes at least one form of glioblastoma (GBM), the most common type of malignant brain tumor.
The findings are reported in the online edition of the journal Cancer Research.
Perhaps more importantly, the…
Added by MySDScience on November 18, 2011 at 11:00am — No Comments
Researchers at the University of California, San Diego School of Medicine and Kyushu University Medical School say a novel combination of a specific sugar molecule with a pair of cell-killing drugs prompts a wide variety of cancer cell types to kill themselves, a process called apoptosis or programmed cell death.
The findings are reported online in the journal Cancer Research.
“The goal of targeted therapy is to stop the growth…
Added by MySDScience on November 16, 2011 at 10:30am — No Comments
Two independent teams of cancer researchers, chemists, and bio-informatics engineers have published discoveries that…Continue
Added by MySDScience on October 24, 2011 at 6:00pm — No Comments
Men who took 400 international units (I.U.) of vitamin E daily had more prostate cancers compared to men who took a placebo, according to an updated review of data from the Selenium and Vitamin E Cancer Prevention (SELECT) Trial. The results of…
Added by MySDScience on October 11, 2011 at 6:00pm — No Comments
LA JOLLA, Calif., October 6, 2011 – In cancer, genes turn on and off at the wrong times, proteins aren’t folded properly, and cellular growth and proliferation get out of control. Even a cancer cell’s metabolism goes haywire, as it loses the ability to appropriately sense nutrients and use them to generate energy. One particular piece of cellular machinery that is known to malfunction in a number of cancers is a group of proteins called mTORC1. This master control…
Added by MySDScience on October 6, 2011 at 8:00pm — No Comments
LA JOLLA, Calif., October 3, 2011 – Glioblastoma is one of the most aggressive forms of brain cancer. Rather than presenting as a well-defined tumor, glioblastoma will often infiltrate the surrounding brain tissue, making it extremely difficult to treat surgically or with chemotherapy or radiation. Likewise, several mouse models of glioblastoma have proven completely resistant to all treatment attempts. In a new study, a team led by scientists at Sanford-Burnham…
Added by MySDScience on October 5, 2011 at 4:00pm — No Comments
San Diego, CA — The National Cancer Institute (NCI) has awarded biomedical device start-up NanoSort, Inc. a 2 year, $297,000 Small Business Innovation Research (SBIR) grant and a 9-month, $198,000 contract. NanoSort will develop devices to detect circulating tumor cells (CTCs)—an emerging target in cancer diagnostics— using two novel approaches. NanoSort applies lab-on-a-chip technologies to drastically reduce the size and cost of flow cytometers while maintaining high…Continue
Added by Jose Morachis on September 27, 2011 at 10:00pm — No Comments
September 12, 2011
LA JOLLA, CA—Oncologists have long sought a powerful "magic bullet" that can find tumors wherever they hide in the body so that they can be imaged and then…Continue
Added by MySDScience on September 13, 2011 at 7:30am — No Comments
Winners receive up to $100K to commercialize innovations
|With the proposed technology, the physician can review, revise, and approve a new treatment plan using a smart phone to interact with the GPU cloud. Photo Credit: Steve Jiang, UC San Diego Moores Cancer Center.|
Five teams of scientists from multiple…Continue
Added by MySDScience on September 8, 2011 at 10:31am — No Comments
LA JOLLA, CA – August 31, 2011 - Scientists at The Scripps Research Institute have shown that a particular white blood cell plays a direct role in the development and spread of cancerous tumors. Their work sheds new light on the development of the disease and points toward novel strategies for treating early-stage cancers.
Added by MySDScience on August 31, 2011 at 9:00am — No Comments
|Scouting nanoparticles (blue) find tumor cells, then broadcast their location. Responding nanoparticles (red) swarm to the location carrying payloads of drugs, concentrating treatment where it is needed.|
Like swarming insects drawing crowds to a food source, a system of nanoparticles and engineered proteins can…Continue
Added by MySDscience Admin on July 18, 2011 at 1:30am — No Comments