LA JOLLA, CA—Researchers at the Salk Institute have discovered a startling feature of early brain development that helps to explain how complex neuron wiring patterns are programmed using just a handful of critical genes. The findings, published in Cell, may help scientists develop new therapies for neurological disorders, such as amyotrophic lateral sclerosis (ALS), and provide insight into certain cancers.
The Salk researchers discovered that only a…
Added by MySDScience on February 10, 2012 at 12:00pm — No Comments
LA JOLLA, CA—Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists at the Salk Institute for Biological Studies have studied organ development in mice to unravel how breast cancers, and perhaps other cancers, develop in people. Their findings provide new ways to predict and personalize the diagnosis and treatment of cancer.
In a paper published February 3…
Added by MySDScience on February 7, 2012 at 12:00pm — No Comments
LA JOLLA, CA—One of the big mysteries in biology is why cells age. Now scientists at the Salk Institute for Biological Studies report that they have discovered a weakness in a component of brain cells that may explain how the aging process occurs in the brain.
The scientists discovered that certain proteins, called extremely long-lived proteins (ELLPs), which are found on the surface of the nucleus of neurons, have a remarkably long lifespan.
While the…
Added by MySDScience on February 3, 2012 at 12:00pm — No Comments
LA JOLLA, CA—Lora B. Sweeney, a postdoctoral researcher at the Salk Institute for Biological Studies has been named a Damon Runyon Fellow.
The Damon Runyon Cancer Research Foundation, a non-profit organization focused on supporting innovative early career researchers, selected Sweeney as one of only 18 recipients at its fall Fellowship Award Committee review. The prestigious $156,000 award is intended to encourage the nation's most-promising young investigators…
Added by MySDScience on January 26, 2012 at 12:00pm — No Comments
LA JOLLA, CA—Scientists at the Salk Institute for Biological Studies have identified a gene that tells cells to develop multiple cilia, tiny hair-like structures that move fluids through the lungs and brain. The finding may help scientists generate new therapies that use stem cells to replace damaged tissues in the lung and other organs.
"Cells with multiple cilia play a number of important roles, including moving fluids through the respiratory tract, brain and spinal cord," says …
ContinueAdded by MySDScience on January 11, 2012 at 12:30pm — No Comments
LA JOLLA, CA—Scientists at the Salk Institute for Biological Studies have identified a gene that tells cells to develop multiple cilia, tiny hair-like structures that move fluids through the lungs and brain. The finding may help scientists generate new therapies that use stem cells to replace damaged tissues in the lung and other organs.
"Cells with multiple cilia play a number of important roles, including moving fluids through the respiratory tract, brain and spinal cord," says …
ContinueAdded by MySDScience on January 11, 2012 at 12:30pm — No Comments
LA JOLLA, CA—Researchers at the Salk Institute for Biological Studies have developed a way to use patients' own cells to potentially cure sickle cell disease and many other disorders caused by mutations in a gene that helps produce blood hemoglobin.
The technique uses cells from a patient's skin to generate induced pluripotent stem cells (iPSCs), which are capable of developing into various types of mature tissues—including blood. The scientists say their method,…
Added by MySDScience on December 7, 2011 at 3:30pm — No Comments
LA JOLLA, CA—The Salk Institute is pleased to announce the appointment of five faculty members to be recipients of endowed chairs established by philanthropic leaders in support of scientific research.
The creation of three new chairs and the rededication of two existing chairs is a testament to the strong commitment of private donors who support the Salk Institute and its groundbreaking research. These significant endowments will provide crucial resources to support the laboratories…
ContinueAdded by MySDScience on November 17, 2011 at 10:30am — No Comments
LA JOLLA, CA—An international team of scientists has created super-strong, high-endurance mice and worms by suppressing a natural muscle-growth inhibitor, suggesting treatments for age-related or genetics-related muscle degeneration are within reach.
The project was a collaboration between researchers at the Salk Institute for Biological Studies, and two Swiss institutions, Ecole Polytechnique Federale de Lausanne (EPFL) and the …
ContinueAdded by MySDScience on November 14, 2011 at 10:30am — No Comments
LA JOLLA, CA—One of the few reliable ways to extend an organism's lifespan, be it a fruit fly or a mouse, is to restrict calorie intake. Now, a new study in fruit flies is helping to explain why such minimal diets are linked to longevity and offering clues to the effects of aging on stem cell behavior.
Scientists at the Salk Institute for Biological Studies and their collaborators found that tweaking a gene known as PGC-1, which is also found in human DNA, in the intestinal stem cells…
ContinueAdded by MySDScience on November 2, 2011 at 5:00pm — 1 Comment
LA JOLLA, CA—A new class of anti-inflammatory drugs may one day serve as an alternative to steroid medications and possibly help avoid the serious side effects of steroids, based on research findings at the Salk Institute for Biological Studies.
The scientists, led by Inder M. Verma, a professor in Salk's Laboratory of Genetics and…
ContinueAdded by MySDScience on October 24, 2011 at 6:00pm — No Comments
WASHINGTON, DC—The National Academy of Sciences (NAS) announces the appointment of Inder M. Verma, Ph.D., as editor-in-chief of the Proceedings of the National Academy of Sciences (PNAS), the official NAS journal. He will formally assume the editorship on November 1, and the transition to the new position will occur over several weeks.
An…
ContinueAdded by MySDScience on October 19, 2011 at 4:00pm — No Comments
LA JOLLA, CA—A discovery by scientists at the Salk Institute for Biological Studies might explain why some premature infants fail to respond to existing treatments for a deadly respiratory distress syndrome (RDS) and offers clues for new ways to treat the breathing disorder.
The scientists identified a new form of RDS in newborn mice and traced the problem to a cellular receptor for thyroid hormone, a key player in many developmental processes in the body. They found that two drugs…
ContinueAdded by MySDScience on October 17, 2011 at 4:00pm — No Comments
LA JOLLA—The National Institutes of Health has announced that the Salk Institute will receive $4.5 million to establish a Neuroscience Core Center, a new research center intended to accelerate brain research that lays the foundation for developing new ways to treat congenital brain defects and neurological diseases.
The new center is one of three established nationally this year by the National Institute of Neurological Disorders and Stroke to focus on basic brain research. More than…
ContinueAdded by MySDScience on October 12, 2011 at 4:00pm — No Comments
LA JOLLA, Calif., October 3, 2011 – Glioblastoma is one of the most aggressive forms of brain cancer. Rather than presenting as a well-defined tumor, glioblastoma will often infiltrate the surrounding brain tissue, making it extremely difficult to treat surgically or with chemotherapy or radiation. Likewise, several mouse models of glioblastoma have proven completely resistant to all treatment attempts. In a new study, a team led by scientists at Sanford-Burnham…
Added by MySDScience on October 5, 2011 at 4:00pm — No Comments
LA JOLLA, CA—Ever wondered why you wake up in the morning—even when the alarm clock isn't making jarring noises? Wonder no more. Researchers at the Salk Institute for Biological Studies have identified a new component of the biological clock, a gene responsible for starting the clock from its restful state every morning.
The biological clock ramps up our metabolism early each day, initiating important physiological functions that tell our bodies that it's time to rise and shine.…
ContinueAdded by MySDScience on September 30, 2011 at 8:00am — 1 Comment
Only 17 T-R01 projects were selected throughout the country and will be supported with a total of…
ContinueAdded by MySDScience on September 29, 2011 at 8:30am — No Comments
LA JOLLA, CA—Researchers at the Salk Institute have discovered how a hormone turns on a series of molecular switches inside the pancreas that increases production of insulin.
The finding, published today in the Proceedings of the National Academy of Sciences, raises the possibility that new designer drugs might be able to turn on key molecules in this pathway to help the 80 million Americans who have type 2 diabetes or pre-diabetic insulin resistance.
The molecular…
ContinueAdded by MySDScience on September 26, 2011 at 7:05pm — No Comments
LA JOLLA—A strain of genetically enhanced bacteria developed by researchers at the Salk Institute for Biological Studies may pave the way for new synthetic drugs and new ways of manufacturing medicines and biofuels, according to a paper published September 18 in Nature Chemical Biology.
For the first…
ContinueAdded by MySDScience on September 23, 2011 at 10:36am — No Comments
Added by MySDScience on September 23, 2011 at 10:35am — No Comments
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