The trouble with most anti-cancer therapies is that they are lethal to most cells in the body, not just cancer cells. As a result, patients experience side effects like nausea, increased susceptibility to infection, and increased risk of developing secondary cancers later in life. Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) are developing techniques to deliver cancer drugs directly to tumors, increasing their effectiveness and decreasing collateral damage. In…
ContinueAdded by MySDScience on November 21, 2011 at 12:00pm — No Comments
LA JOLLA, Calif., November 17, 2011 – Mitochondria are often called cellular “powerhouses” because they convert nutrients into energy. But these tiny structures also help determine cellular lifespan. Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) are now discovering how mitochondria alternate between duplicating and fragmenting and how these events help cells adapt to diverse physiological conditions. In a paper published November 18…
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LA JOLLA, Calif., November 3, 2011 – Sanford-Burnham Medical Research Institute (Sanford-Burnham) is the latest research organization to partner with Pfizer, Inc. as part of Pfizer’s commitment to transforming research and development through a focus on translational medicine. The Centers for Therapeutic Innovation (CTI) is a research unit at Pfizer dedicated to open innovation through establishing global partnerships with academic research institutions to bridge the gap…
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Two independent teams of cancer researchers, chemists, and bio-informatics engineers have published discoveries that…
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LA JOLLA, Calif., October 6, 2011 – In cancer, genes turn on and off at the wrong times, proteins aren’t folded properly, and cellular growth and proliferation get out of control. Even a cancer cell’s metabolism goes haywire, as it loses the ability to appropriately sense nutrients and use them to generate energy. One particular piece of cellular machinery that is known to malfunction in a number of cancers is a group of proteins called mTORC1. This master control…
Added by MySDScience on October 6, 2011 at 8:00pm — No Comments
LA JOLLA, Calif., October 3, 2011 – Glioblastoma is one of the most aggressive forms of brain cancer. Rather than presenting as a well-defined tumor, glioblastoma will often infiltrate the surrounding brain tissue, making it extremely difficult to treat surgically or with chemotherapy or radiation. Likewise, several mouse models of glioblastoma have proven completely resistant to all treatment attempts. In a new study, a team led by scientists at Sanford-Burnham…
Added by MySDScience on October 5, 2011 at 4:00pm — No Comments
LA JOLLA, Calif., September 19, 2011 – The Board of Trustees of Sanford-Burnham Medical Research Institute (Sanford-Burnham) voted unanimously at their September 14 board meeting to endorse the California Cancer Research Act (CCRA), making it the first non-profit research…
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